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MicroRNAs in ischaemic cardiovascular diseases.

ABSTRACT: microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

SUBMITTER: Greco S

PROVIDER: S-EPMC5421236 | biostudies-other | 2016 Apr

REPOSITORIES: biostudies-other

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microRNAs in ischaemic cardiovascular diseases.

Greco Simona S Zaccagnini Germana G Voellenkle Christine C Martelli Fabio F

European heart journal supplements : journal of the European Society of Cardiology 20160429 Suppl E

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular dis ...[more]

PMID: 28533714

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