Clarification of contraceptive drug pharmacokinetics in obesity.
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ABSTRACT:
SUBMITTER: Jusko WJ
PROVIDER: S-EPMC5422994 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Publications
Clarification of contraceptive drug pharmacokinetics in obesity.
Contraception 20160816 1
Related to concerns about the role of obesity in the efficacy of contraceptive drugs, a review of the literature was carried out in regard to the pharmacokinetics of ethinyl estradiol and various progestins given by various routes of administration. Most studies show that obese women exhibit modestly lower plasma concentrations of these drugs (circa 30%) when given the same doses as normal-weight women. While the mechanism is uncertain, precedence in the literature suggests that this is due to b ...[more]
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