Unknown

Dataset Information

0

A distinctive family of embryonic protein-tyrosine kinase receptors.


ABSTRACT: Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.

SUBMITTER: Pasquale EB 

PROVIDER: S-EPMC54418 | biostudies-other | 1990 Aug

REPOSITORIES: biostudies-other

altmetric image

Publications

A distinctive family of embryonic protein-tyrosine kinase receptors.

Pasquale E B EB  

Proceedings of the National Academy of Sciences of the United States of America 19900801 15


Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 esta  ...[more]

Similar Datasets

| S-EPMC7696731 | biostudies-literature
| S-EPMC4252886 | biostudies-literature
| S-EPMC49256 | biostudies-other
| S-EPMC395287 | biostudies-other
| S-EPMC2121056 | biostudies-other
| S-EPMC6602532 | biostudies-literature
| S-EPMC4394290 | biostudies-literature
| S-EPMC4977182 | biostudies-literature
| S-EPMC2133004 | biostudies-literature
| S-EPMC4941224 | biostudies-literature