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Data Management and Data Quality in PERCH, a Large International Case-Control Study of Severe Childhood Pneumonia.

ABSTRACT: The Pneumonia Etiology Research for Child Health (PERCH) study is the largest multicountry etiology study of pediatric pneumonia undertaken in the past 3 decades. The study enrolled 4232 hospitalized cases and 5325 controls over 2 years across 9 research sites in 7 countries in Africa and Asia. The volume and complexity of data collection in PERCH presented considerable logistical and technical challenges. The project chose an internet-based data entry system to allow real-time access to the data, enabling the project to monitor and clean incoming data and perform preliminary analyses throughout the study. To ensure high-quality data, the project developed comprehensive quality indicator, data query, and monitoring reports. Among the approximately 9000 cases and controls, analyzable laboratory results were available for ?96% of core specimens collected. Selected approaches to data management in PERCH may be extended to the planning and organization of international studies of similar scope and complexity.

SUBMITTER: Watson NL 

PROVIDER: S-EPMC5447839 | biostudies-other | 2017 Jun

REPOSITORIES: biostudies-other

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Data Management and Data Quality in PERCH, a Large International Case-Control Study of Severe Childhood Pneumonia.

Watson Nora L NL   Prosperi Christine C   Driscoll Amanda J AJ   Higdon Melissa M MM   Park Daniel E DE   Sanza Megan M   DeLuca Andrea N AN   Awori Juliet O JO   Goswami Doli D   Hammond Emily E   Hossain Lokman L   Johnson Catherine C   Kamau Alice A   Kuwanda Locadiah L   Moore David P DP   Neyzari Omid O   Onwuchekwa Uma U   Parker David D   Sapchookul Patranuch P   Seidenberg Phil P   Shamsul Arifin A   Siazeele Kazungu K   Srisaengchai Prasong P   Sylla Mamadou M   Levine Orin S OS   Murdoch David R DR   O'Brien Katherine L KL   Wolff Mark M   Deloria Knoll Maria M  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20170601 suppl_3

The Pneumonia Etiology Research for Child Health (PERCH) study is the largest multicountry etiology study of pediatric pneumonia undertaken in the past 3 decades. The study enrolled 4232 hospitalized cases and 5325 controls over 2 years across 9 research sites in 7 countries in Africa and Asia. The volume and complexity of data collection in PERCH presented considerable logistical and technical challenges. The project chose an internet-based data entry system to allow real-time access to the dat  ...[more]