Ontology highlight
ABSTRACT:
SUBMITTER: Omoto S
PROVIDER: S-EPMC544868 | biostudies-other | 2004
REPOSITORIES: biostudies-other
Retrovirology 20041215
<h4>Background</h4>MicroRNAs (miRNAs) are 21 to approximately 25-nucleotides (nt) long and interact with mRNAs to trigger either translational repression or RNA cleavage through RNA interference (RNAi), depending on the degree of complementarity with the target mRNAs. Our recent study has shown that HIV-1 nef dsRNA from AIDS patients who are long-term non-progressors (LTNPs) inhibited the transcription of HIV-1.<h4>Results</h4>Here, we show the possibility that nef-derived miRNAs are produced in ...[more]