Ontology highlight
ABSTRACT:
SUBMITTER: Ram S
PROVIDER: S-EPMC5449626 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Ram Sanjay S Shaughnessy Jutamas J de Oliveira Rosane B RB Lewis Lisa A LA Gulati Sunita S Rice Peter A PA
Pathogens and disease 20170601 4
Gonorrhea has become resistant to most conventional antimicrobials used in clinical practice. The global spread of multidrug-resistant isolates of Neisseria gonorrhoeae could lead to an era of untreatable gonorrhea. New therapeutic modalities with novel mechanisms of action that do not lend themselves to the development of resistance are urgently needed. Gonococcal lipooligosaccharide (LOS) sialylation is critical for complement resistance and for establishing infection in humans and experimenta ...[more]