Ontology highlight
ABSTRACT:
SUBMITTER: Lachowski D
PROVIDER: S-EPMC5451433 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Lachowski Dariusz D Cortes Ernesto E Pink Daniel D Chronopoulos Antonios A Karim Saadia A SA P Morton Jennifer J Del Río Hernández Armando E AE
Scientific reports 20170531 1
Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the poor response of patients to systemic therapies. Pancreatic stellate cells (PSCs) are key mediators in the production of this fibrotic stroma, upon activation transitioning to a myofibroblast-like, high matrix secreting phenotype. Given their importance in disease progression, characterisation of PSC activation has been extensive, however o ...[more]