Ontology highlight
ABSTRACT:
SUBMITTER: Lao PJ
PROVIDER: S-EPMC5454131 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Lao Patrick J PJ Handen Ben L BL Betthauser Tobey J TJ Mihaila Iulia I Hartley Sigan L SL Cohen Annie D AD Tudorascu Dana L DL Bulova Peter D PD Lopresti Brian J BJ Tumuluru Rameshwari V RV Murali Dhanabalan D Mathis Chester A CA Barnhart Todd E TE Stone Charles K CK Price Julie C JC Devenny Darlynne A DA Mailick Marsha R MR Klunk William E WE Johnson Sterling C SC Christian Bradley T BT
Alzheimer's & dementia (Amsterdam, Netherlands) 20170523
<h4>Introduction</h4>Down syndrome (DS) arises from a triplication of chromosome 21, causing overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's disease (AD).<h4>Methods</h4>Fifty-two nondemented adults with DS underwent two cycles of carbon 11-labeled Pittsburgh compound B ([<sup>11</sup>C]PiB) and T1 weighted magnetic resonance imaging (MRI) scans 3.0 ± 0.6 years apart. Standard uptake value ratio (SUVR) images (50-70 minutes; cerebellar gray matter ...[more]