Ontology highlight
ABSTRACT:
SUBMITTER: Mak E
PROVIDER: S-EPMC5454799 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Mak Elijah E Su Li L Williams Guy B GB Firbank Michael J MJ Lawson Rachael A RA Yarnall Alison J AJ Duncan Gordon W GW Mollenhauer Brit B Owen Adrian M AM Khoo Tien K TK Brooks David J DJ Rowe James B JB Barker Roger A RA Burn David J DJ O'Brien John T JT
Neurobiology of aging 20170316
We investigated whole-brain atrophy and ventricular enlargement over 18 months in nondemented Parkinson's disease (PD) and examined their associations with clinical measures and baseline CSF markers. PD subjects (n = 100) were classified at baseline into those with mild cognitive impairment (MCI; PD-MCI, n = 36) and no cognitive impairment (PD-NC, n = 64). Percentage of whole-brain volume change (PBVC) and ventricular expansion over 18 months were assessed with FSL-SIENA and ventricular enlargem ...[more]