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Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.

ABSTRACT: As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 ?M) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 ?g/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 ?g/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.

SUBMITTER: Aronsson P

PROVIDER: S-EPMC5456303 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.

Aronsson Per P Munissi Joan J E JJE Gruhonjic Amra A Fitzpatrick Paul A PA Landberg Göran G Nyandoro Stephen S SS Erdelyi Mate M

Diseases (Basel, Switzerland) 20160115 1

As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plum ...[more]

PMID: 28933383

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Dataset Information

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.

Publications

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from <i>Diospyros shimbaensis</i>.

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