Directing cell migration with asymmetric micropatterns.
Ontology highlight
ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC545855 | biostudies-other | 2005 Jan
REPOSITORIES: biostudies-other
Publications
Directing cell migration with asymmetric micropatterns.
Jiang Xingyu X Bruzewicz Derek A DA Wong Amy P AP Piel Matthieu M Whitesides George M GM
Proceedings of the National Academy of Sciences of the United States of America 20050114 4
This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward ...[more]
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