Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Discrete Element Method Simulations of the Inter-Particle Contact Parameters for the Mono-Sized Iron Ore Particles.

ABSTRACT: Aiming at predicting what happens in reality inside mills, the contact parameters of iron ore particles for discrete element method (DEM) simulations should be determined accurately. To allow the irregular shape to be accurately determined, the sphere clump method was employed in modelling the particle shape. The inter-particle contact parameters were systematically altered whilst the contact parameters between the particle and wall were arbitrarily assumed, in order to purely assess its impact on the angle of repose for the mono-sized iron ore particles. Results show that varying the restitution coefficient over the range considered does not lead to any obvious difference in the angle of repose, but the angle of repose has strong sensitivity to the rolling/static friction coefficient. The impacts of the rolling/static friction coefficient on the angle of repose are interrelated, and increasing the inter-particle rolling/static friction coefficient can evidently increase the angle of repose. However, the impact of the static friction coefficient is more profound than that of the rolling friction coefficient. Finally, a predictive equation is established and a very close agreement between the predicted and simulated angle of repose is attained. This predictive equation can enormously shorten the inter-particle contact parameters calibration time that can help in the implementation of DEM simulations.

SUBMITTER: Li T

PROVIDER: S-EPMC5459068 | biostudies-other | 2017 May

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Nano-sized and micro-sized polystyrene particles affect phagocyte function.

Project description:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocytes and macrophages were studied. Carboxyl polystyrene (CPS) particles in sizes between 20 and 1,000 nm served as model particles. Twenty nanometers CPS particles were taken up passively, while larger CPS particles entered cells actively and passively. Twenty nanometers CPS were cytotoxic to all phagocytes, ≥500 nm CPS particles only to macrophages. Twenty nanometers CPS particles stimulated IL-8 secretion in human monocytes and induced oxidative burst in monocytes. Five hundred nanometers and 1,000 nm CPS particles stimulated IL-6 and IL-8 secretion in monocytes and macrophages, chemotaxis towards a chemotactic stimulus of monocytes and phagocytosis of bacteria by macrophages and provoked an oxidative burst of granulocytes. At very high concentrations, CPS particles of 20 and 500 nm stimulated myeloperoxidase release of granulocytes and nitric oxide generation in macrophages. Cytotoxic effect could contribute to some of the observed effects. In the absence of cytotoxicity, 500 and 1,000 nm CPS particles appear to influence phagocyte function to a greater extent than particles in other sizes.

| S-EPMC4434214 | biostudies-literature

Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products.

Project description:ObjectiveDevelop and validate particular, concrete, and abstract yet plausible in silico mechanistic explanations for large intra- and interindividual variability observed for eleven bioequivalence study participants. Do so in the face of considerable uncertainty about mechanisms.MethodsWe constructed an object-oriented, discrete event model called subject (we use small caps to distinguish computational objects from their biological counterparts). It maps abstractly to a dissolution test system and study subject to whom product was administered orally. A subject comprises four interconnected grid spaces and event mechanisms that map to different physiological features and processes. Drugs move within and between spaces. We followed an established, Iterative Refinement Protocol. Individualized mechanisms were made sufficiently complicated to achieve prespecified Similarity Criteria, but no more so. Within subjects, the dissolution space is linked to both a product-subject Interaction Space and the GI tract. The GI tract and Interaction Space connect to plasma, from which drug is eliminated.ResultsWe discovered parameterizations that enabled the eleven subject simulation results to achieve the most stringent Similarity Criteria. Simulated profiles closely resembled those with normal, odd, and double peaks. We observed important subject-by-formulation interactions within subjects.ConclusionWe hypothesize that there were interactions within bioequivalence study participants corresponding to the subject-by-formulation interactions within subjects. Further progress requires methods to transition currently abstract subject mechanisms iteratively and parsimoniously to be more physiologically realistic. As that objective is achieved, the approach presented is expected to become beneficial to drug development (e.g., controlled release) and to a reduction in the number of subjects needed per study plus faster regulatory review.

| S-EPMC3563477 | biostudies-literature

Moisture Determination for Fine-Sized Copper Ore by Computer Vision and Thermovision Methods.

Project description:The moisture of bulk material has a significant impact on the energetic efficiency of dry grinding, resultant particle size distribution and particle shape, and conditions of powder transport. This research aims to develop computer vision and thermovision techniques for the on-site estimation of moisture content in copper ore, for use, e.g., in dry grinding installations. The influence of particle size on the results of moisture estimation is also studied. The tested granular material was copper ore of particle size 0-2 mm and relative moisture content of 0.5-11%. Both vision and thermovision images were taken at standard and macro scales. The results suggest that median-intensity vision images monotonically reflect copper ore moisture in the range of about 0.5-5%. Suitable models were identified and cross-validated here. In contrary, thermograms should not be analyzed simply for their mean temperature but treated with computer vision processing algorithms.

| S-EPMC9920960 | biostudies-literature

Calibration and test of contact parameters for alfalfa stalk at primary florescence based on discrete element method.

Project description:In view of the lack of accurate models for discrete element simulation in the current research and development process of forage harvesting and crushing machinery, the contact parameters were calibrated based on Hertz-Mindlin (no slip) contact model by EDEM simulation software with alfalfa stalk at primary florescence as the research object. Based on the angle of repose, the restitution coefficient, static friction coefficient, rolling friction coefficient of alfalfa stalks were determined through the Placket-Burman test, steepest ascent test and Box-Behnken test. The simulation test of the repose angle was carried out with the determined contact parameters. The results showed that the relative error between the simulated repose angle and the physical test repose angle was 0.48%, which indicated that the calibrated contact parameters could truly reflect the physical characteristics of alfalfa stalks at the primary florescence. It provided a reliable model and parameter calibration method for the discrete element simulation in the research and development process of forage machinery, and also provided a reference for the research and optimization design of forage harvesting, crushing and processing machinery.

| S-EPMC11361690 | biostudies-literature

Discrete plasticity in sub-10-nm-sized gold crystals.

Project description:Although deformation processes in submicron-sized metallic crystals are well documented, the direct observation of deformation mechanisms in crystals with dimensions below the sub-10-nm range is currently lacking. Here, through in situ high-resolution transmission electron microscopy (HRTEM) observations, we show that (1) in sharp contrast to what happens in bulk materials, in which plasticity is mediated by dislocation emission from Frank-Read sources and multiplication, partial dislocations emitted from free surfaces dominate the deformation of gold (Au) nanocrystals; (2) the crystallographic orientation (Schmid factor) is not the only factor in determining the deformation mechanism of nanometre-sized Au; and (3) the Au nanocrystal exhibits a phase transformation from a face-centered cubic to a body-centered tetragonal structure after failure. These findings provide direct experimental evidence for the vast amount of theoretical modelling on the deformation mechanisms of nanomaterials that have appeared in recent years.

| S-EPMC3105591 | biostudies-literature

Human-sized magnetic particle imaging for brain applications.

Project description:Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmolFe ml-1, which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.

| S-EPMC6486595 | biostudies-literature

Interaction of various-sized particles in river flow.

Project description:Sediment transport is essential to the source-sink systems; however, the interaction between two complex multiscale nonlinear systems, turbulence of the river flow and wide size sediment, has heretofore restricted our understanding of sediment motion. We have conducted flume experiments deploying a video-based technique that records sediment transport rate of each particle size at 1 s resolution. The observations reveal detailed interactions between flow and particles of sizes ranging from 0.5 to 32 mm, such that small suspended particles (< ~ 5 mm) keep swirling in the wake vortices of the keystones (larger than 20 mm) until large to very-large-scale coherent structures destroy the wake vortices and bring the small particles downstream. Keystones destabilize consequently as the surrounding small and intermediate particles move, and in turn, a group of sheltered particles is entrained following the dislodging of the keystones. This heuristic model highlights the interactions of turbulence and different-sized particles.

| S-EPMC10307775 | biostudies-literature

Nucleation of Biomolecular Condensates from Finite-Sized Simulations.

Project description:The nucleation of protein condensates is a concentration-driven process of assembly. When modeled in the canonical ensemble, condensation is affected by finite-size effects. Here, we present a general and efficient route for obtaining ensemble properties of protein condensates in the macroscopic limit from finite-sized nucleation simulations. The approach is based on a theoretical description of droplet nucleation in the canonical ensemble and enables estimation of thermodynamic and kinetic parameters, such as the macroscopic equilibrium density of the dilute protein phase, the surface tension of the condensates, and nucleation free energy barriers. We apply the method to coarse-grained simulations of NDDX4 and FUS-LC, two phase-separating disordered proteins with different physicochemical characteristics. Our results show that NDDX4 condensate droplets, characterized by lower surface tension, higher solubility, and faster monomer exchange dynamics compared to those of FUS-LC, form with negligible nucleation barriers. In contrast, FUS-LC condensates form via an activated process over a wide range of concentrations.

| S-EPMC9940850 | biostudies-literature

Optomechanical crystals for spatial sensing of submicron sized particles.

Project description:Optomechanical crystal cavities (OMC) have rich perspectives for detecting and indirectly analysing biological particles, such as proteins, bacteria and viruses. In this work we demonstrate the working principle of OMCs operating under ambient conditions as a sensor of submicrometer particles by optically monitoring the frequency shift of thermally activated mechanical modes. The resonator has been specifically designed so that the cavity region supports a particular family of low modal-volume mechanical modes, commonly known as -pinch modes-. These involve the oscillation of only a couple of adjacent cavity cells that are relatively insensitive to perturbations in other parts of the resonator. The eigenfrequency of these modes decreases as the deformation is localized closer to the centre of the resonator. Thus, by identifying specific modes that undergo a frequency shift that amply exceeds the mechanical linewidth, it is possible to infer if there are particles deposited on the resonator, how many are there and their approximate position within the cavity region. OMCs have rich perspectives for detecting and indirectly analysing biological particles, such as proteins, viruses and bacteria.

| S-EPMC8035185 | biostudies-literature

Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia.

Project description:Magnetic particle hyperthermia (MPH) enables the direct heating of solid tumors with alternating magnetic fields (AMFs). One challenge with MPH is the unknown particle distribution in tissue after injection. Magnetic particle imaging (MPI) can measure the nanoparticle content and distribution in tissue after delivery. The objective of this study was to develop a clinically translatable protocol that incorporates MPI data into finite element calculations for simulating tissue temperatures during MPH. To verify the protocol, we conducted MPH experiments in tumor-bearing mouse cadavers. Five 8-10-week-old female BALB/c mice bearing subcutaneous 4T1 tumors were anesthetized and received intratumor injections of Synomag®-S90 nanoparticles. Immediately following injection, the mice were euthanized and imaged, and the tumors were heated with an AMF. We used the Mimics Innovation Suite to create a 3D mesh of the tumor from micro-computerized tomography data and spatial index MPI to generate a scaled heating function for the heat transfer calculations. The processed imaging data were incorporated into a finite element solver, COMSOL Multiphysics®. The upper and lower bounds of the simulated tumor temperatures for all five cadavers demonstrated agreement with the experimental temperature measurements, thus verifying the protocol. These results demonstrate the utility of MPI to guide predictive thermal calculations for MPH treatment planning.

| S-EPMC11206764 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data