Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC5464811 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Oncotarget 20170501 20
Hexokinases II (HK2) is a hub in the regulation of cancer cell glycolysis. Here we reported deguelin, a natural compound which has been studied in various tumor types, has a profound anti-tumor effect on human non-small cell lung cancer (NSCLC) via directly down-regulating of glycolysis. In NSCLC cell lines and primary NSCLC tissue, we found HK2 is overexpressed. Deguelin treatment markedly inhibited anchorage-dependent and independent growth of NSCLC cell lines. We revealed that deguelin exposu ...[more]