Ontology highlight
ABSTRACT:
SUBMITTER: Boucher JM
PROVIDER: S-EPMC5467243 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Boucher Joshua M JM Clark Ryan P RP Chong Diana C DC Citrin Kathryn M KM Wylie Lyndsay A LA Bautch Victoria L VL
Nature communications 20170607
Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. Here we show that dynamic regulation of mVEGFR1 stability and turnover in blood vessels impacts angiogenesis. mVEGFR1 is highly stable and constitutively internalizes from the plasm ...[more]