Ontology highlight
ABSTRACT:
SUBMITTER: Cherayil BJ
PROVIDER: S-EPMC54736 | biostudies-other | 1990 Sep
REPOSITORIES: biostudies-other
Cherayil B J BJ Chaitovitz S S Wong C C Pillai S S
Proceedings of the National Academy of Sciences of the United States of America 19900901 18
The murine Mac-2 protein is a galactose- and IgE-binding lectin secreted by inflammatory macrophages. We describe here the cloning and characterization of a cDNA representing the human homolog of Mac-2 (hMac-2). The amino acid sequence derived from the hMac-2 cDNA indicates that the protein is evolutionarily highly conserved, with 85% of its amino acid residues being similar to those in the murine homolog. This conservation is especially marked in the carboxyl-terminal lectin domain. The amino-t ...[more]