Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC5473856 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Wu Qi Q Li Zhubing Z Mellor Paul P Zhou Yan Y Anderson Deborah H DH Liu Qiang Q
Scientific reports 20170616 1
Hepatitis C virus (HCV) infection leads to severe liver diseases including hepatocellular carcinoma (HCC). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumour suppressor, is frequently mutated or deleted in HCC tumors. PTEN has previously been demonstrated to inhibit HCV secretion. In this study, we determined the effects of PTEN on the other steps in HCV life cycle, including entry, translation, and replication. We showed that PTEN inhibits HCV entry through its lipid phosp ...[more]