Ontology highlight
ABSTRACT:
SUBMITTER: Papadaki G
PROVIDER: S-EPMC5476297 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Papadaki Garyfalia G Kambas Konstantinos K Choulaki Christiana C Vlachou Katerina K Drakos Elias E Bertsias George G Ritis Konstantinos K Boumpas Dimitrios T DT Thompson Paul R PR Verginis Panayotis P Sidiropoulos Prodromos P
European journal of immunology 20161005 11
Aberrant formation of neutrophil extracellular traps (NETs) is a key feature in rheumatoid arthritis (RA) and plays a pivotal role in disease pathogenesis. However, the mechanism through which NETs shape the autoimmune response in RA remains elusive. In this study, we demonstrate that inhibition of peptidylarginine deiminases activity in collagen-induced arthritis (CIA) mouse model significantly reduces NET formation, attenuates clinical disease activity, and prevents joint destruction. Importan ...[more]