Ontology highlight
ABSTRACT:
SUBMITTER: Noeske J
PROVIDER: S-EPMC547832 | biostudies-other | 2005 Feb
REPOSITORIES: biostudies-other
Noeske Jonas J Richter Christian C Grundl Marc A MA Nasiri Hamid R HR Schwalbe Harald H Wöhnert Jens J
Proceedings of the National Academy of Sciences of the United States of America 20050121 5
Riboswitches are highly structured RNA elements that control the expression of many bacterial genes by binding directly to small metabolite molecules with high specificity and affinity. In Bacillus subtilis, two classes of riboswitches have been described that discriminate between guanine and adenine despite an extremely high degree of homology both in their primary and secondary structure. We have identified intermolecular base triples between both purine ligands and their respective riboswitch ...[more]