Ontology highlight
ABSTRACT:
SUBMITTER: Sai J
PROVIDER: S-EPMC5479746 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Sai Jiqing J Owens Philip P Novitskiy Sergey V SV Hawkins Oriana E OE Vilgelm Anna E AE Yang Jinming J Sobolik Tammy T Lavender Nicole N Johnson Andrew C AC McClain Colt C Ayers Gregory D GD Kelley Mark C MC Sanders Melinda M Mayer Ingrid A IA Moses Harold L HL Boothby Mark M Richmond Ann A
Clinical cancer research : an official journal of the American Association for Cancer Research 20161221 13
<b>Purpose:</b> Metastatic breast cancers continue to elude current therapeutic strategies, including those utilizing PI3K inhibitors. Given the prominent role of PI3Kα,β in tumor growth and PI3Kγ,δ in immune cell function, we sought to determine whether PI3K inhibition altered antitumor immunity.<b>Experimental Design:</b> The effect of PI3K inhibition on tumor growth, metastasis, and antitumor immune response was characterized in mouse models utilizing orthotopic implants of 4T1 or PyMT mammar ...[more]