Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC5479809 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Yuan Yi Y Han Qiuju Q Li Siyu S Tian Zhigang Z Zhang Jian J
Scientific reports 20170621 1
The Wingless-type MMTV integration site family member 2b (Wnt2b) has been found to be a principal mediator of liver development and regeneration. However, the significance of Wnt2b in the pathogenesis of fibrosis-related liver diseases remains undefined. Here, we report that Wnt2b was highly expressed in the fibrotic liver tissues, exhibiting protective effects against activation of hepatic stellate cells (HSCs) and fibrosis progression. We identified a negative regulation of Wnt2b on the toll-l ...[more]