Ontology highlight
ABSTRACT:
SUBMITTER: Yoshizaki Y
PROVIDER: S-EPMC5479848 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Yoshizaki Yuki Y Mori Takayasu T Ishigami-Yuasa Mari M Kikuchi Eriko E Takahashi Daiei D Zeniya Moko M Nomura Naohiro N Mori Yutaro Y Araki Yuya Y Ando Fumiaki F Mandai Shintaro S Kasagi Yuri Y Arai Yohei Y Sasaki Emi E Yoshida Sayaka S Kagechika Hiroyuki H Rai Tatemitsu T Uchida Shinichi S Sohara Eisei E
Scientific reports 20170621 1
The Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. The Cul3/Keap1 E3 ubiquitin ligase complex interacts with Nrf2, leading to Nrf2 ubiquitination and degradation. In this study, we focused on the disruption of the Keap1-Nrf2 interaction to upregulate Nrf2 expression and the transcription of ARE-controlled c ...[more]