Ontology highlight
ABSTRACT:
SUBMITTER: Borzova VA
PROVIDER: S-EPMC5479853 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Borzova Vera A VA Markossian Kira A KA Kleymenov Sergey Yu SY Kurganov Boris I BI
Scientific reports 20170621 1
Chemical chaperones including arginine and its derivatives are widely used by biochemists working on the design of agents, which are able to efficiently suppress protein aggregation. To elucidate the mechanisms of anti-aggregation activity of chemical chaperones, methods based on registration of the increment in light scattering intensity must be supplemented with methods for direct detection of the portion of aggregated protein (γ<sub>agg</sub>). For this purpose asymmetric flow field-flow frac ...[more]