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Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block.

ABSTRACT: The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disaccharide building block.

SUBMITTER: Isoda Y

PROVIDER: S-EPMC5480352 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block.

Isoda Yuta Y Sasaki Norihiko N Kitamura Kei K Takahashi Shuji S Manmode Sujit S Takeda-Okuda Naoko N Tamura Jun-Ichi JI Nokami Toshiki T Itoh Toshiyuki T

Beilstein journal of organic chemistry 20170516

The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disac ...[more]

PMID: 28684973

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