Ontology highlight
ABSTRACT:
SUBMITTER: Quarta M
PROVIDER: S-EPMC5481841 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Nature communications 20170620
Volumetric muscle loss (VML) is associated with loss of skeletal muscle function, and current treatments show limited efficacy. Here we show that bioconstructs suffused with genetically-labelled muscle stem cells (MuSCs) and other muscle resident cells (MRCs) are effective to treat VML injuries in mice. Imaging of bioconstructs implanted in damaged muscles indicates MuSCs survival and growth, and ex vivo analyses show force restoration of treated muscles. Histological analysis highlights myofibr ...[more]