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Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.

ABSTRACT: Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pathway in chronic pancreatitis.

SUBMITTER: Hegyi E

PROVIDER: S-EPMC5487703 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.

Hegyi Eszter E Sahin-Tóth Miklós M

Digestive diseases and sciences 20170523 7

Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pa ...[more]

PMID: 28536777

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