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Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice.

ABSTRACT: Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primordial germ cells travel to the genital ridge and start differentiating into germ cells would result in a transgenerational inheritance of increased mammary cancer risk.Pregnant C57BL/6NTac mouse dams were fed either a control AIN93G or isocaloric HF diet composed of corn oil high in n-6 polyunsaturated fatty acids between gestational days 10 and 20. Offspring in subsequent F1-F3 generations were fed only the control diet.Mammary tumor incidence induced by 7,12-dimethylbenz[a]anthracene was significantly higher in F1 (p?

SUBMITTER: Nguyen NM 

PROVIDER: S-EPMC5494892 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice.

Nguyen Nguyen M NM   de Oliveira Andrade Fabia F   Jin Lu L   Zhang Xiyuan X   Macon Madisa M   Cruz M Idalia MI   Benitez Carlos C   Wehrenberg Bryan B   Yin Chao C   Wang Xiao X   Xuan Jianhua J   de Assis Sonia S   Hilakivi-Clarke Leena L  

Breast cancer research : BCR 20170703 1

<h4>Background</h4>Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primordial germ cells travel to the genital ridge and start differentiating into germ cells would result in a transgenerational inheritance of increased mammary cancer risk.<h4>Methods</h4>Pregnant C57BL/6NTac mouse dams were fed either a control AIN93G or  ...[more]