Ontology highlight
ABSTRACT:
SUBMITTER: Kohno T
PROVIDER: S-EPMC54949 | biostudies-other | 1990 Nov
REPOSITORIES: biostudies-other
Kohno T T Brewer M T MT Baker S L SL Schwartz P E PE King M W MW Hale K K KK Squires C H CH Thompson R C RC Vannice J L JL
Proceedings of the National Academy of Sciences of the United States of America 19901101 21
An inhibitor of tumor necrosis factor (TNF) has been isolated from the human histiocytic lymphoma cell line U-937 that is capable of inhibiting both TNF-alpha and TNF-beta. Protein sequencing has verified that it is distinct from a previously described TNF inhibitor that is a soluble fragment of a TNF receptor molecule (TNFrI). The cDNA sequence of this second TNF inhibitor clone suggests that it is also a soluble fragment of a TNF receptor. Expression of this cDNA sequence in COS-7 cells verifi ...[more]