Ontology highlight
ABSTRACT:
SUBMITTER: Jiang C
PROVIDER: S-EPMC5498918 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Jiang Chunhui C Cano-Vega Mario Alberto MA Yue Feng F Kuang Liangju L Narayanan Naagarajan N Uzunalli Gozde G Merkel Madeline P MP Kuang Shihuan S Deng Meng M
Molecular therapy : the journal of the American Society of Gene Therapy 20170616 7
Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the location and temporal extent of beige adipocyte biogenesis. Here, we demonstrate an alternative approach to stimulate browning using nanoparticles (NPs) composed of FDA-approved poly(lactide-co-glyco ...[more]