Ribo-seq enlightens codon usage bias.
Ontology highlight
ABSTRACT:
SUBMITTER: Paulet D
PROVIDER: S-EPMC5499818 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Publications
Ribo-seq enlightens codon usage bias.
Paulet Damien D David Alexandre A Rivals Eric E
DNA research : an international journal for rapid publication of reports on genes and genomes 20170601 3
Codon usage is biased between lowly and highly expressed genes in a genome-specific manner. This universal bias has been well assessed in some unicellular species, but remains problematic to assess in more complex species. We propose a new method to compute codon usage bias based on genome wide translational data. A new technique based on sequencing of ribosome protected mRNA fragments (Ribo-seq) allowed us to rank genes and compute codon usage bias with high precision for a great variety of spe ...[more]
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