Same same but different: The evolution of TBP in archaea and their eukaryotic offspring.

ABSTRACT: Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.

SUBMITTER: Blombach F 

PROVIDER: S-EPMC5501381 | biostudies-other | 2017 May

REPOSITORIES: biostudies-other