Ontology highlight
ABSTRACT:
SUBMITTER: Mulay SR
PROVIDER: S-EPMC5504458 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
Mulay Shrikant R SR Eberhard Jonathan N JN Pfann Victoria V Marschner Julian A JA Darisipudi Murthy N MN Daniel Christoph C Romoli Simone S Desai Jyaysi J Grigorescu Melissa M Kumar Santhosh V SV Rathkolb Birgit B Wolf Eckhard E Hrabě de Angelis Martin M Bäuerle Tobias T Dietel Barbara B Wagner Carsten A CA Amann Kerstin K Eckardt Kai-Uwe KU Aronson Peter S PS Anders Hans Joachim HJ Knauf Felix F
American journal of physiology. Renal physiology 20160113 8
Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice. Renal histology is characterized by tubular damage, remnant atubular glomeruli, interstitial inflammation, and fibrosis, with the extent of tissue involvement depending on the duration of oxalate feeding. Expression profiling of ma ...[more]