Ontology highlight
ABSTRACT:
SUBMITTER: Rifat D
PROVIDER: S-EPMC5506874 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Future microbiology 20170327
<h4>Aim</h4>There is controversy regarding the potential fitness costs of rifampicin (RIF) resistance-conferring mutations in the Mycobacterium tuberculosis (Mtb) rpoB gene. We characterized the pathogenicity of an Mtb RpoB H526D mutant.<h4>Materials & methods</h4>A mutant containing the RpoB H526D mutation was isolated from wild-type Mtb grown on RIF-containing plates and complemented for determination of in vitro and in vivo fitness costs.<h4>Results</h4>The RpoB H526D mutant showed reduced su ...[more]