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A Special Connection between ?? T Cells and Natural Antibodies?

ABSTRACT: Natural antibodies (NAbs) play an important role in early host defense, autophagy and tissue remodeling, and in immune regulation. They arise spontaneously (without specific immunization), and are already present at birth. NAbs are produced by B1 B cells, MZ B cells and other B cell types. They include all major Ig subclasses but IgM antibodies are prevalent, especially early in development. NAbs may be poly-specific, recognize particular auto-antigens, or detect neo-determinants such as those exposed during apoptosis or generated by oxidation. NAbs do not require cognate T cell help but depend on soluble mediators produced by T cells. Our recent studies suggest that ?? T cells may have a special relationship with NAbs, and play a prominent role in their regulation, in part through the fine-tuning of IL-4 levels. The spontaneously activated state of these cells likely enables their cytokine production and other functions in the absence of external stimulation. Ontogenetically, the earlier arising ?? T cells are better positioned than ?? T cells to shape the developing repertoire of NAbs. Intriguingly, ligand specificities of NAbs and ?? T cell receptors appear to be overlapping, perhaps allowing ?? cognate help for certain NAb specificities. Via NAbs, ?? T cells could exert a regulatory influence on numerous processes in health and disease.

SUBMITTER: Born WK

PROVIDER: S-EPMC5507014 | biostudies-other | 2016 Dec

REPOSITORIES: biostudies-other

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A Special Connection between γδ T Cells and Natural Antibodies?

Born Willi K WK Huang Yafei Y Zeng Wanjiang W Torres Raul M RM O'Brien Rebecca L RL

Archivum immunologiae et therapiae experimentalis 20160527 6

Natural antibodies (NAbs) play an important role in early host defense, autophagy and tissue remodeling, and in immune regulation. They arise spontaneously (without specific immunization), and are already present at birth. NAbs are produced by B1 B cells, MZ B cells and other B cell types. They include all major Ig subclasses but IgM antibodies are prevalent, especially early in development. NAbs may be poly-specific, recognize particular auto-antigens, or detect neo-determinants such as those e ...[more]

PMID: 27235134

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Dataset Information

A Special Connection between ?? T Cells and Natural Antibodies?

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A Special Connection between γδ T Cells and Natural Antibodies?

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