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Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.

ABSTRACT: Callisalignenes G-I (1-3), three new meroterpenoids of ?-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC50 values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 ?M, respectively. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.

SUBMITTER: Qin XJ

PROVIDER: S-EPMC5507812 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

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Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.

Qin Xu-Jie XJ Shu Tong T Yu Qian Q Yan Huan H Ni Wei W An Lin-Kun LK Li Pan-Pan PP Zhi Yin-E YE Khan Afsar A Liu Hai-Yang HY

Natural products and bioprospecting 20170615 4

Callisalignenes G-I (1-3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1-3 exhibited cytotoxicity against HCT116 cells with IC<sub>50</sub> values of 8.51 ...[more]

PMID: 28620873

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