Ontology highlight
ABSTRACT:
SUBMITTER: Giacomini E
PROVIDER: S-EPMC5507879 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Giacomini Elisa E Vago Riccardo R Sanchez Ana Maria AM Podini Paola P Zarovni Natasa N Murdica Valentina V Rizzo Roberta R Bortolotti Daria D Candiani Massimo M Viganò Paola P
Scientific reports 20170712 1
Communication between embryo and maternal endometrium occurs during a specific time frame in which implantation is possible. Here we demonstrate for the first time that conditioned media from non-manipulated human embryos cultured in vitro for 3 days or up to the blastocyst stage contain extracellular vesicles (EVs) with a diameter of 50 to 200 nm and bearing the traditional microvesicle and exosome marker proteins CD63, CD9 and ALIX. The embryonic origin of these EVs has been confirmed by the p ...[more]