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Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects.


ABSTRACT: The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects.High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matched healthy individuals. Using a combined volumetric and surface-based morphometric approach, the structural variability of the lateral ventricles, with respect to extent and location, was examined.Methamphetamine-dependent subjects had an enlarged right lateral ventricle compared with healthy individuals. Morphometric analysis revealed a region-specific pattern of lateral ventricular expansion associated with methamphetamine dependence, which was mainly distributed in the areas adjacent to the ventral striatum, medial prefrontal cortex, and thalamus.Patterns of shape decomposition in the lateral ventricles may have relevance to the structural vulnerability of the prefrontal-ventral striatal-thalamic circuit to methamphetamine-induced neurotoxicity.

SUBMITTER: Jeong HS 

PROVIDER: S-EPMC5510466 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other

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Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects.

Jeong Hyeonseok S HS   Lee Sunho S   Yoon Sujung S   Jung Jiyoung J JJ   Cho Han Byul HB   Kim Binna N BN   Ma Jiyoung J   Ko Eun E   Im Jooyeon Jamie JJ   Ban Soonhyun S   Renshaw Perry F PF   Lyoo In Kyoon IK  

Drug and alcohol dependence 20130612 3


<h4>Background</h4>The presence of morphometric abnormalities of the lateral ventricles, which can reflect focal or diffuse atrophic changes of nearby brain structures, is not well characterized in methamphetamine dependence. The current study was aimed to examine the size and shape alterations of the lateral ventricles in methamphetamine-dependent subjects.<h4>Methods</h4>High-resolution brain structural images were obtained from 37 methamphetamine-dependent subjects and 25 demographically matc  ...[more]

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