Ontology highlight
ABSTRACT:
SUBMITTER: Attri KS
PROVIDER: S-EPMC5511627 | biostudies-other | 2017 Mar
REPOSITORIES: biostudies-other
Attri Kuldeep S KS Murthy Divya D Singh Pankaj K PK
Frontiers in bioscience (Landmark edition) 20170301 8
Genetic mutations and metabolic reprogramming are two key hallmarks of cancer, required for proliferation, invasion, and metastasis of the disease. While genetic mutations, whether inherited or acquired, are critical for the initiation of tumor development, metabolic reprogramming is an effector mechanism imperative for adaptational transition during the progression of cancer. Recent findings in the literature emphasize the significance of molecular cross-talk between these two cellular processe ...[more]