Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin.
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ABSTRACT:
SUBMITTER: Chang J
PROVIDER: S-EPMC5512289 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Publications
Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin.
Chang J J Coffman L L Kim S J SJ
Chemical communications (Cambridge, England) 20170501 41
The mode of action for desleucyl-oritavancin was investigated by adding an antibiotic to Staphylococcus aureus during its growth in a defined medium containing l,d-[1-<sup>15</sup>N]Ala and l-[1-<sup>13</sup>C]Lys, or d-[1-<sup>15</sup>N]Ala. <sup>13</sup>C{<sup>15</sup>N} and <sup>15</sup>N{<sup>13</sup>C} rotational-echo double resonance NMR determined that desleucyl-oritavancin inhibited the incorporation of d-[1-<sup>15</sup>N]Ala into wall teichoic acid. ...[more]
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