ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC5512318 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
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ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Li Shitao S Fu Bishi B Wang Lingyan L Dorf Martin E ME
DNA and cell biology 20170608 7
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common an ...[more]
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