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Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics.

ABSTRACT: We performed an observational study with very-low-birth weight infants (VLBWI) ?33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n?=?8534, n?=?6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the administration of probiotics was independently associated with improved weight gain [g/d; effect size B?=?0.62 (95% CI: 0.37-0.87), p?

SUBMITTER: Hartel C

PROVIDER: S-EPMC5514087 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics.

Härtel Christoph C Pagel Julia J Spiegler Juliane J Buma Janne J Henneke Philipp P Zemlin Michael M Viemann Dorothee D Gille Christian C Gehring Stephan S Frommhold David D Rupp Jan J Herting Egbert E Göpel Wolfgang W

Scientific reports 20170717 1

We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the admini ...[more]

PMID: 28717131

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