Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5518870 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Liu Xinjian X Li Fang F Huang Qian Q Zhang Zhengxiang Z Zhou Ling L Deng Yu Y Zhou Min M Fleenor Donald E DE Wang He H Kastan Michael B MB Li Chuan-Yuan CY
Cell research 20170324 6
DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can drive tumor growth irrespective of their effects on genomic stability. We discover a mechanism through which cancer cells cause DSBs in their own genome spontaneously independent of reactive oxygen species or replication stress. In this mechanism, low-level cytochrome c leakage from th ...[more]