MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5520902 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Publications
MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.
Chen Xin X Jiang Xue-Mei XM Zhao Lin-Jing LJ Sun Lin-Lin LL Yan Mei-Ling ML Tian You Y Zhang Shuai S Duan Ming-Jing MJ Zhao Hong-Mei HM Li Wen-Rui WR Hao Yang-Yang YY Wang Li-Bo LB Xiong Qiao-Jie QJ Ai Jing J
Cell death & disease 20170601 6
Impaired synaptic plasticity and neuron loss are hallmarks of Alzheimer's disease and vascular dementia. Here, we found that chronic brain hypoperfusion (CBH) by bilateral common carotid artery occlusion (2VO) decreased the total length, numbers and crossings of dendrites and caused neuron death in rat hippocampi and cortices. It also led to increase in N-terminal β-amyloid precursor protein (N-APP) and death receptor-6 (DR6) protein levels and in the activation of caspase-3 and caspase-6. Furth ...[more]
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