Ontology highlight
ABSTRACT:
SUBMITTER: Leonard GA
PROVIDER: S-EPMC55214 | biostudies-other | 1990 Dec
REPOSITORIES: biostudies-other
Leonard G A GA Thomson J J Watson W P WP Brown T T
Proceedings of the National Academy of Sciences of the United States of America 19901201 24
The self-complementary dodecanucleotide d[CGC(m6G)AATTTGCG]2 (where m6G is O6-methylguanine), which contains two m6G.T base pairs, has been analyzed by x-ray diffraction methods and the structure has been refined to a residual error of R = 0.185 at 2.0-A resolution. The m6G.T mispair closely resembles a Watson-Crick base pair and there are very few structural differences between the m6G.T duplex and the native analogue. The similarity between the m6G.T base pair and a normal G.C base pair explai ...[more]