Ontology highlight
ABSTRACT:
SUBMITTER: Tian B
PROVIDER: S-EPMC5522068 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Tian Baoqing B Chen Xiaojia X Zhang Huihua H Li Xiaoyan X Wang Jiakang J Han Wei W Zhang Li-Yi LY Fu Li L Li Yan Y Nie Changjun C Zhao Ying Y Tan Xuan X Wang Hailong H Guan Xin-Yuan XY Hong An A
Oncotarget 20170601 26
Cancer-associated fibroblasts (CAFs) are believed to influence tumor behavior and clinical outcomes. We previously showed that conditioned medium (CM) from CAFs induces proliferation and motility of esophageal squamous cell carcinoma (ESCC) cells. Here, we investigated the molecular mechanisms by which the CAF-secreted proteins induce ESCC development and progression. Using antibody arrays, we identified urokinase plasminogen activator (uPA) as one of the main proteins whose release was increase ...[more]