MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics.
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ABSTRACT:
SUBMITTER: Welch JD
PROVIDER: S-EPMC5525279 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Publications
MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics.
Welch Joshua D JD Hartemink Alexander J AJ Prins Jan F JF
Genome biology 20170724 1
Single cell experimental techniques reveal transcriptomic and epigenetic heterogeneity among cells, but how these are related is unclear. We present MATCHER, an approach for integrating multiple types of single cell measurements. MATCHER uses manifold alignment to infer single cell multi-omic profiles from transcriptomic and epigenetic measurements performed on different cells of the same type. Using scM&T-seq and sc-GEM data, we confirm that MATCHER accurately predicts true single cell correlat ...[more]
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