Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5526719 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Journal of immunology (Baltimore, Md. : 1950) 20170621 3
Th17 cells are critical effectors mediating the ocular surface autoimmunity in dry eye disease (DED). Increased IFN-γ has also been implicated in DED; however, it remains unclear to what extent Th1 cells contribute to DED pathogenesis. In this study, we investigated the cellular source of IFN-γ and assessed its contribution to corneal epitheliopathy in DED mice. We discovered a significant IL-17A<sup>+</sup>IFN-γ<sup>+</sup> (Th17/1) population and determined that these cells are derived from Th ...[more]