Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC5527079 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Li Xian X Lee Youn Ju YJ Jin Fansi F Park Young Na YN Deng Yifeng Y Kang Youra Y Yang Ju Hye JH Chang Jae-Hoon JH Kim Dong-Young DY Kim Jung-Ae JA Chang Young-Chae YC Ko Hyun-Jeong HJ Kim Cheorl-Ho CH Murakami Makoto M Chang Hyeun Wook HW
Scientific reports 20170725 1
Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation of allergic reactions, although the underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation and anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) and protein tyrosine phosphatase 1B (PTP1B). Mast cell-specific knockout of Sirt1 dampened AMPK-dependent suppression of FcεRI signaling, ther ...[more]