Ontology highlight
ABSTRACT:
SUBMITTER: Lee HJ
PROVIDER: S-EPMC5528162 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Lee Hyun Joo HJ Weitz Andrew J AJ Bernal-Casas David D Duffy Ben A BA Choy ManKin M Kravitz Alexxai V AV Kreitzer Anatol C AC Lee Jin Hyung JH
Neuron 20160630 2
A central theory of basal ganglia function is that striatal neurons expressing the D1 and D2 dopamine receptors exert opposing brain-wide influences. However, the causal influence of each population has never been measured at the whole-brain scale. Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-brain activity with fMRI. Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited s ...[more]