Ontology highlight
ABSTRACT:
SUBMITTER: Hong SS
PROVIDER: S-EPMC5529536 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Hong Saw-See SS Marotte Hubert H Courbon Guillaume G Firestein Gary S GS Boulanger Pierre P Miossec Pierre P
Nature communications 20170727 1
In rheumatoid arthritis (RA), the proliferation of fibroblast-like synoviocytes (FLS) is the cause of chronic inflammation in joints and of joint damage. Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is hampered by low transduction, as FLS do not express HAdV5 receptors on the cell surface. Here we show that efficient transduction of PUMA in FLS can be achieved by conjugating HAdV5 to a baculov ...[more]