Unknown

Dataset Information

0

Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells.


ABSTRACT: Lung cancer is one of the leading causes of cancer-associated mortality, worldwide. The overall survival rate remains low, but progress has been made in improving the diagnosis and treatment of lung cancer over the past decades. Niclosamide, a salicylanilide derivative used for the treatment of tapeworm infections, is safe, well tolerated, inexpensive and readily available. Previous studies have identified niclosamide as a potential anticancer agent. The present study demonstrated that niclosamide enhanced the effect of irradiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway. These findings suggest that niclosamide may be a promising candidate for clinical evaluation as part of a combined regimen for the treatment of non-small cell lung cancer.

SUBMITTER: Xiang M 

PROVIDER: S-EPMC5530112 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC9761153 | biostudies-literature
| S-EPMC10445209 | biostudies-literature
| S-EPMC5238385 | biostudies-literature
| S-EPMC3923075 | biostudies-literature
| S-EPMC4318952 | biostudies-literature
| S-EPMC5240658 | biostudies-literature
| S-EPMC4559849 | biostudies-literature
| S-EPMC3322979 | biostudies-literature
| S-EPMC4242664 | biostudies-literature
| S-EPMC5376042 | biostudies-literature